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The world of Darwinia is a virtual themepark, running entirely inside a computer network and populated by a sentient evolving life form called the Darwinians. Unfortunately Darwinia has been overrun by a computer virus which has multiplied out of control. Your task is to destroy the Viral Infection and save the Darwinians from extinction. Don't forget to look at the video.
Here is the Darwania Trailer
Combining fast-paced action with strategic battle planning, Darwinia features a novel and intuitive control mechanism, a graphical style ripped from 80's retro classics like Tron and Defender, and a story concerning a tribe of nomadic sprites trapped in a modern 3D world.
This game was released via direct download in March of 2005 by Introversion Software and Pinnacle Software, with a box copy release in June of 2006 by Cinemaware Marquee.
Interesting controls, such as using the mouse to draw units; mixture of 2D and 3D graphics create a visually unique world.